We know compliance and persistence cause poor patient outcomes. When you add the possibility of resistance, you end up with highly complex interactions that are very difficult to assess. Before changing doses or medications, the first goal, according to this article, is to address non-compliance. Doctors need to know what they’re measuring to make the best decisions for treatment. As frustrating as it may be, change is a process; and it can take a long time. The better the communication, the better the decisions, the better the outcome.