Friday, July 10, 2009

C&P in GERD Medications

Using national claims data, researchers have now compiled adherence information on 10,159 patients with Barrett’s esophagus (BE) and 48,965 patients with gastroesophageal reflux disease (GERD) diagnosed between 2000 and 2005 who were taking oral proton pump inhibitors (PPIs) or histamine-2 receptor antagonists (H2RAs). On average the mean duration of filled PPI or H2RA prescriptions accounted for only 31.7% of the year and only 66.6% (BE) or 60.4% (GERD) of patients actually filled PPI prescriptions. The average therapy duration was 241 days for PPIs, and 159 days for H2RAs. Finally, those without BE diagnoses were less adherent, as were individuals diagnosed in 2005 vs. 2000. Overall, this shows a similar pattern to other chronic conditions, which show generally poor adherence and persistence with more severe diagnoses being associated with greater compliance.